The effect of empagliflozin on inflammation and oxidative stress in patients undergoing percutaneous coronary intervention, a randomized controlled trial
Abstract
Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current evidence on its short-term impact on inflammation and oxidative stress is limited. The purpose of this study was to investigate the rapid anti-inflammatory and oxidative effects of short-term Empagliflozin therapy in patients undergoing percutaneous coronary intervention (PCI). In this double-blind, placebo-controlled, randomized clinical trial, patients with cardiovascular disease (CVD) undergoing PCI received 10 mg Empagliflozin or placebo for three days. Biomarkers of inflammation and oxidative stress, including cystatin C, pro-oxidant-antioxidant balance (PAB), and high-sensitive C-reactive protein (hs-CRP), were measured at baseline and after treatment. The Jamovi 2.7.6 software was used for statistical analysis. A total of 121 patients, including 64 males (52.8%), were enrolled. There was no significant difference in baseline characteristics between the groups. Empagliflozin significantly reduced cystatin C and PAB levels after three days of administration compared with baseline (p < 0.001, p < 0.001, respectively). Although Empagliflozin decreased hs-CRP levels, the reduction did not reach statistical significance (p = 0.14). Nevertheless, the between-group difference in hs-CRP changes became significant after adjustment (p =…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 121 participants or records.
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