The Comparison of the Effect of Adding Empagliflozin to the Medication Regimen on Peripheral Neuropathy in Patients With Type II Diabetes: A Double Blind Randomised Clinical Trial
Abstract
Introduction: Diabetes is the common metabolic disorder. Empagliflozin is a new medication that acts as a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It promotes increased glucose excretion through urine, which helps improve blood sugar control, enhances glucose metabolism, and reduces glucotoxicity and insulin resistance. This study aimed to investigate and compare the effects of adding empagliflozin to a medication regimen on peripheral neuropathy in diabetes.
Materials and methods: This study involved 50 patients with diabetic neuropathy, confirmed by the Michigan Neuropathy Screening Instrument, who were randomly assigned to two groups. The control group continued their previous medication regimen with a placebo, while the treatment group added 10 mg of empagliflozin daily to their existing regimen. At the start of the study, fasting blood glucose, haemoglobin A1c, serum creatinine levels and electrophysiological findings (including amplitude, latency and nerve conduction velocity) were assessed for all patients. These parameters were re-evaluated at the end of the 20-week intervention, and the results were analysed using statistical software.
Results: At the end of the study, there was a significant reduction in both haemoglobin A1c and fasting blood glucose levels in the treatment group. Serum creatinine levels also significantly decreased. eGFR (estimated glomerular filtration rate) increased in the treatment group. In the Michigan Neuropathy Screening…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 50 participants or records.
Read the paper
Related studies
- Strategy for Mitigating DKA Risk in Patients with Type 1 Diabetes on Adjunctive Treatment with SGLT Inhibitors: A STICH Protocol
- Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance
- SGLT2 Inhibitors in Heart Failure: Targeted Metabolomics and Energetic Metabolism
- Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors
- Sodium-glucose cotransporter inhibitors: beyond glycaemic control
- Decoding the effects of SGLT2 inhibitors on cardiac arrhythmias in heart failure
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.