AVP-825 Breath-Powered Intranasal Delivery System Containing 22 mg Sumatriptan Powder vs 100 mg Oral Sumatriptan in the Acute Treatment of Migraines (The COMPASS Study): A Comparative Randomized Clinical Trial Across Multiple Attacks
Abstract
The objective of this study was to compare the efficacy, tolerability, and safety of AVP‐825, an investigational bi‐directional breath‐powered intranasal delivery system containing low‐dose (22 mg) sumatriptan powder, vs 100 mg oral sumatriptan for acute treatment of migraine in a double‐dummy, randomized comparative efficacy clinical trial allowing treatment across multiple migraine attacks.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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