Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial
Abstract
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), although the exact molecular mechanisms underlying their cardioprotective effects remain to be fully elucidated. The EmDia study, a randomized, double-blind trial conducted at the University Medical Center of Mainz, has confirmed the beneficial effects of Empagliflozin in HF patients after both one and twelve weeks of treatment. In this work, we aimed to assess whether changes in lipid profiles driven by Empagliflozin use in HF patients in the EmDia trial could assist in gaining a better understanding of its cardioprotective mechanisms.
Methods: Lipid analysis of blood plasma from 144 patients from the EmDia trial was conducted using 4D-LC-TIMS/IMS lipidomics. Lipid signatures after treatment for one and twelve weeks, respectively, were obtained with sparse group LASSO regularized regression models. Linear regression models were employed to highlight associations between significantly changed clinical traits and lipids.
Results: The lipid signatures after one week of treatment consisted of 37 lipids from the lipid groups lysophosphatidylcholine (LPC), phosphatidylcholine (PC), phosphatidylethanolamine (PE), sphingomyelin (SM), and triacylglycerol (TG). After twelve weeks, the signature comprised 24 lipids from the same five lipid groups, along with Ceramides (Cer).…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 144 participants or records.
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