The Changes on Electroretinogram Following Sildenafil Ingestion
Abstract
Purpose: Sildenafil citrate ()acts as a relatively specific inhibitor of the type 5 phosphodiesterase isoenzyme (PDE5) in the corpus cavernosum. But, it also has a mild inhibitory effect on PDE6 in the retinal photoreceptor. Therefore, we studied the ocular side effects of sildenafil. Methods: We tested the visual acuity, intraocular pressure, color vision, visual evoked potential (VEP), lectroretinogram (ERG), anterior segment and fundus appearance. All tests were done before and after medication; of 50 mg and 100 mg sildenafil, respectively. Results: There was no significant effect of sildenafil on visual acuity, intraocular pressure, color vision, VEP, anterior segment and fundus appearance. ERG changes after 50 mg sildenafil were not significant. The a-wave amplitude of the maximal combined response after 100 mg sildenafil showed significant changes (p=-0.021). The b-wave amplitude of the maximal combined response after 100 mg sildenafil showed changes with borderline significance (p=0.059). Conclusions: In considering the fact that even single dose of 100 mg sildenafil showed changes on ERG, it seems that retinal function in patients receiving sildenafil for a longer-period, especially in patients with underlying vascular abnormalities should be monitored by clinical and electrophysiologic tests.
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