Anti-inflammatory, Antipyretic and Analgesic Activities of Persimmon (Diospyros kaki) Leaves in Animal Model
Abstract
Diospyros kaki L. (Ebenaceae) fruit and leaves are traditionally used for the treatment of hypertension and angina, as well as for their antithrombotic and anti-inflammatory effects. We investigated the anti-inflammatory, analgesic and antipyretic activities of Diospyros kaki L. (Ebenaceae) in order to scientifically validate its pharmacological importance. In the current study, the anti-inflammatory, analgesic and antipyretic activities of ethyl acetate (Per-1), n-butanol (Per-2) and aqueous (Per-3) fractions of a methanol extract of Persimmon leaves were tested. Wistar rats weighing 190–210 g (for the anti-inflammatory assay) and male albino mice (Swiss) weighing 18–24 g (for the antipyretic and analgesic assays) were utilized as the experimental animals. The rats were separated into eight groups (for anti-inflammatory) and seven group (for antipyretic), each consisting of six rats. Each sample was treated orally and two doses: 100 and 200 mg/kg body weight were used in these experiments. The Per-3 sample at a dose of 200 mg/kg produced the highest inflammation inhibition at 59.28%. The same sample at a dose of 200 mg/kg lowered body temperature from 38°C of hyperthermia mice back to 36.65 ± 0.12°C after 120 min, close to the normal temperature (35.21 ± 0.29°C). In the tail flick model, sample Per-3 showed 67.74% highest nociception inhibition. Similar results were obtained with Acetic acid and hot-plate assay. These results confirm that the n-butanol and aqueous fractions…
Read the paper
Related studies
- Drug repositioning: a brief overview
- Cyclic nucleotide phosphodiesterases in Drosophila melanogaster
- Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation
- Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions
- In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer’s Disease
- Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.