Aphrodisiac Potential of Hibiscus sabdariffa: Phosphodiesterse-5 Inhibition and Sexual Behavior Study Using in Silico and in Vivo Models
Abstract
Background: Driven by in vitro, in silico, and in vivo studies, the current work investigates the therapeutic potential of Hibiscus sabdariffa L. flower extract in modulating male sexual function through phosphodiesterase-5 (PDE-5) inhibition. Sexual dysfunction cause is also a s metabolic disorder. The bioactive components including gossypitrin, luteolin, hibiscetin-3-glucoside, and delphinidin-3-sambubioside, were found using molecular docking studies to have beneficial binding affinities for PDE-5 that were either higher than or equivalent to those of the reference with sildenafil. The stability and potent intermolecular interactions of these compounds within the PDE-5 active site have been further demonstrated by molecular dynamics (MD) simulation, indicating their potential pharmacological significance.Methods: To assess the extract's impact on male genitals, in vivo tests were carried out on rat’s models. at doses of 100, 200, and 400 mg/kg, the animals were split into five groups: Measurements of parameters like mount frequency, mount latency, and intromission delay showed that sexual performance improved in a dose-dependent manner. Results: The behavioral results were supported by biochemical analyses that showed a substantial rise in serum testosterone levels and nitric oxide concentration. Furthermore, the extract's PDE-5 inhibitory efficacy validated its mechanism of action in improving erectile function.Conclusions: When combined, the results show that Hibiscus…
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