Formulation, Development And In Vitro Evaluation Of Sildenafil Citrate Lignocaine Hcl Gel
Abstract
The present study was undertaken to formulate, development and in vitro evaluation of Sildenafil Lignocaine gel. Sildenafil citrate is a drug of choice used in the treatment of premature ejaculation disorder. Topical gel has gained more and more importance because the gel based formulations are better percutaneously absorbed than creams and ointment bases. Therefore, topical gel of Sildenafil citrate was prepared using polymer of Carbopol 934 and triethanolamine at different proportions. The study encompasses compatibility studies using FTIR spectra, drug content, viscosity, spreadability, and pH determination. Further the optimized formulation F5 was evaluated by in vitro diffusion study. Optimized formulation batch F5 subjected to stability as well as in vitro study. The preliminary compatibility studies conducted revealed that there was no interaction between Sildenafil citrate and excipients. In vitro drug release study was carried out with Franz diffusion cell using egg membrane in pH 7.4 phosphate buffers as diffusion medium. Formulation batch F5 containing Carbopol 934 and triethanolamine showed 99.09 % drug release at 60 min and 5.55 g.cm /sec spreadability. Result showed that formulation batch F5 showed better drug release at one h. Formulation batch F5 was used further for stability and ex vivo study. Stability studies conducted under accelerated condition were shown satisfactory results. It was concluded that Carbopol gel containing Sildenafil citrate showed good…
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