Chicoric acid, a phytochemical compound of solenostemon monostachyus: possible drug candidate for the relief of erectile dysfunction
Abstract
Solenostemon monostachyus is commonly used in folkloric treatment of many ailments including erectile dysfunction.In this study, its aphrodisiac component and underlying mechanism were investigated.Behavioural evaluation was done, following the oral administration of three different doses (100, 200 and 400 mg/kg) of ethanolic extract of S. monostachyus, sildenafil citrate (Viagra) and corn oil were used as positive and negative controls respectively.Mounting, intromission and ejaculation frequencies, mating performance, and orientation activities towards females.Result showed a striking effect in male rats.Molecular docking was done and heat map generated to probe the likely mechanism of action as invivo studies compared with sildenafil.A library containing 45 phytocompounds previously characterized from S. monostachyus was generated and docked (Autodock Vina) into homology models of Arginase II, Phosphodiesterase 5 and Aromatase.From the docking result above, PDE 5 was identified as a major target for two key compounds, Chicoric acid and Hesperidine.Although the latter violated more than two rules of the Lipinski's rule of oral drug.Conclusion: The results of this study support that Chicoric acids from S. monostachyus may inhibit the activity of PDE5, leading to relaxation of erectile smooth muscles.This finding may underscore the aphrodisiac potency of S .monostachyus
Read the paper
Related studies
- Drug repositioning: a brief overview
- Cyclic nucleotide phosphodiesterases in Drosophila melanogaster
- Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation
- Current View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health Conditions
- In silico Structure-based Identification of Novel Acetylcholinesterase Inhibitors Against Alzheimer’s Disease
- Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.