Lipids, Apolipoproteins, and The Risk of Parkinson's Disease: A Prospective Cohort Study and a Mendelian Randomization Analysis
Abstract
RATIONALE
A complete picture of the associations of the most common lipid fractions, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and apolipoproteins, with the risk of Parkinson's disease (PD), is lacking.
OBJECTIVE
To assess the associations of lipids and apolipoproteins with the future risk of PD.
METHODS AND RESULTS
In the Apolipoprotein-related MOrtality RISk (AMORIS) Study, we enrolled approximately 600,000 participants during 1985-1996 in Stockholm, Sweden, with repeated measurements of total cholesterol, LDL-C, HDL-C, triglycerides, apolipoprotein B (ApoB), and apolipoprotein A-I (ApoA-I). The cohort was followed until the end of 2011 and incident cases of PD were identified through the Swedish Patient Register. We first used Cox models to estimate the associations of these biomarkers with later risk of PD. We further applied a Mendelian randomization analysis for total cholesterol, LDL-C, and triglycerides using the GWAS summary statistics from the public PD GWAS data and 23andMe PD cohorts with more than 800 000 individuals. One standard deviation increase of total cholesterol was associated with a lower hazard of PD (HR [hazard ratio] = 0.90, 95% CI [confidence interval]: 0.87-0.94). Similar associations were observed for LDL-C (HR = 0.93, 95% CI: 0.88-0.98), triglycerides (HR = 0.94, 95% CI: 0.90-0.97), and ApoB (HR = 0.91, 95% CI: 0.85-0.97). A clear dose-response relation…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 600,000 participants or records.
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