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Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis

N. Janssen, R. Nyga, L. Vanderbeke, C. Jacobs, M. Ergün, J. Buil, K. van Dijk, J. Altenburg et al.

Emerging Infectious Diseases, 2021

823 participants · 107 citations

Abstract

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary aspergillosis (CAPA). We found 10%–15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%–52%.

How strong is the evidence?

Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 823 participants or records.

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