SGL-TX-MR-study protocol acute effects of SGLT2 inhibitor on kidney allograft oxygen tension, a randomized, double-blind, placebo controlled crossover trial
Abstract
Background: The acute effect of sodium-glucose co-transporter type 2 inhibitors, SGLT2i, has never been investigated in non-diabetic kidney transplant recipients.
Methods: SGL-TX-MR will investigate the acute effects of SGLT2 inhibitor on kidney allograft oxygen tension in a randomized, double-blind, placebo controlled crossover trial. Eight non-diabetic-KTR, adults, more than 6 months post-transplant with a stable estimated glomerular filtration rate > 20 ml/min, recruited from Odense University Hospital, Kidney Transplant Outpatient Clinic, from 2025 to 2026, will be randomized to a double blind crossover intervention with a single dose 50 mg Jardiance, SGLT2i, or placebo in random order, separated by a 2-week wash-out period.
Primary outcome: kidney transplant cortical and medullary oxygen tension, estimated by blood oxygen level dependent-magnetic resonance imaging-based renal T2* relaxation rate. Secondary endpoint: Renal cortical and medullary perfusion, renal artery blood flow, blood glucose, blood pressure, and heart rate.
Discussion: We will investigate if a single dose of SGLT2i improves renal cortical oxygenation within 3 and 6 h from admission in non-diabetic kidney transplant recipients. This finding will improve the understanding of the mechanisms behind the impressive renoprotective effects recently seen with SGLT2i in major clinical trials with non-transplant chronic kidney disease patients and provide new horizons for therapeutic treatments targeting hypoxia…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa
- Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis
- A methodology for assessing deployment trauma and its consequences in OEF/OIF/OND veterans: The TRACTS longitudinal prospective cohort study
- Post‑COVID‑19 Syndrome in Outpatients: a Cohort Study
- Factors Influencing Primary and Secondary Implant Stability—A Retrospective Cohort Study with 582 Implants in 272 Patients
- Electroacupuncture for Painful Diabetic Peripheral Neuropathy: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.