Risks for Excessive Daytime Sleepiness in Pediatric Brain Tumors
Abstract
Abstract Purpose. Excessive daytime sleepiness (EDS) was previously found to be the most common sleep complaint for youth with central nervous system neoplasms and may occur in up to 82% of youth with brain tumors, depending on diagnosis type. Established risk factors for the development of EDS include grade 2 hypothalamic involvement and high body mass index; however, the identification of additional risk factors across various brain tumor types is limited. Methods. A total of 209 individuals diagnosed with pediatric brain tumors within the last 15 years at an academic medical center in the south were study eligible. Due to no longer receiving medical care, EDS and risk factors were coded through retrospective chart review only for 145. For those receiving active medical care (n = 64), EDS was screened using the Modified Epworth Sleepiness Scale and the Pediatric Hypersomnolence Survey. Risk factors were then coded using retrospective chart review. Results. A total of 147 (70.3%) reported EDS or were diagnosed with a CDH. Independent predictors identified by multivariable logistic regression included higher cancer treatment intensity level, younger age (≤ 6 years), and use of anti-seizure medications. Conclusions. Increased medical provider awareness of EDS, as well as screening at various time points during cancer treatment and survivorship are needed to support more timely detection and intervention. Those diagnosed at a young age with higher treatment burden, and those…
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