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Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial

C. Grudzen, Nina Siman, A. Cuthel, O. Adeyemi, R. Yamarik, K. Goldfeld, Benjamin S. Abella, Fernanda Bellolio et al.

Journal of the American Medical Association (JAMA), 2025

33 citations

Abstract

Importance

The emergency department (ED) offers an opportunity to initiate palliative care for older adults with serious, life-limiting illness.

Objective

To assess the effect of a multicomponent intervention to initiate palliative care in the ED on hospital admission, subsequent health care use, and survival in older adults with serious, life-limiting illness.

Design, Setting, and Participants

Cluster randomized, stepped-wedge, clinical trial including patients aged 66 years or older who visited 1 of 29 EDs across the US between May 1, 2018, and December 31, 2022, had 12 months of prior Medicare enrollment, and a Gagne comorbidity score greater than 6, representing a risk of short-term mortality greater than 30%. Nursing home patients were excluded.

Intervention

A multicomponent intervention (the Primary Palliative Care for Emergency Medicine intervention) included (1) evidence-based multidisciplinary education; (2) simulation-based workshops on serious illness communication; (3) clinical decision support; and (4) audit and feedback for ED clinical staff.

Main Outcome and Measures

The primary outcome was hospital admission. The secondary outcomes included subsequent health care use and survival at 6 months.

Results

There were 98 922 initial ED visits during the study period (median age, 77 years [IQR, 71-84 years]; 50% were female; 13% were Black and 78% were White; and the median Gagne comorbidity score was 8 [IQR, 7-10]). The rate of hospital admission was 64.4% during…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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