Prognostic Clinical Decision Support for Pneumonia in the ED: A Randomized Trial
Abstract
Background: Hospitalizations rates for childhood pneumonia vary widely. Risk-based clinical decision support (CDS) interventions may reduce unwarranted variation. Methods: We conducted a pragmatic randomized trial in two US pediatric EDs comparing electronic health record (EHR)-integrated prognostic CDS vs usual care for promoting appropriate ED disposition in children (70% satisfied). Implementation barriers included intrinsic (e.g., reaching the right person at the right time) and extrinsic factors (i.e., global pandemic). Conclusions: EHR-based prognostic CDS did not improve ED disposition decisions for children with pneumonia. Although the intervention’s content was favorably received, low subject accrual and workflow integration problems likely limited effectiveness.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
- The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
- In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
- In silico prediction of splice-altering single nucleotide variants in the human genome
- In silico clinical trials: how computer simulation will transform the biomedical industry
- In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.