Cardiovascular Implications of Diabetes Mellitus: A Systematic Literature Review
Abstract
Diabetes mellitus is a chronic metabolic disorder associated with a two- to four-fold higher risk of cardiovascular morbidity and mortality compared with individuals without diabetes due to complex interactions between metabolic, inflammatory, and vascular pathways. Despite extensive research, uncertainties remain regarding the integrated effects of emerging therapies and persistent cardiovascular risk in diabetic populations. This systematic literature review aimed to evaluate the cardiovascular implications of diabetes mellitus by synthesizing evidence on epidemiology, mechanisms, and clinical outcomes. A structured search was conducted across PubMed, Scopus, Web of Science, and Cochrane Library for studies published between 2015 and 2025, using predefined Boolean search terms, including MeSH terms in PubMed, to identify randomized controlled trials and observational studies reporting cardiovascular outcomes; no review protocol was registered prospectively. Eleven studies were included in the final review after searches were conducted for studies published between 2015 and 2025. Data were extracted and synthesized narratively because clinical and methodological heterogeneity, including differences in populations, interventions, outcomes, study designs, and follow-up durations, precluded formal meta-analysis, and I² assessment. The findings indicate that diabetes significantly increases the risk of major adverse cardiovascular events, heart failure, and mortality, driven by…
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