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Esophagitis Dissecans Superficialis in a 47-Year-Old Female With Dysphagia and Epigastric Pain: A Case Report

Droznik RG, Zhu MY, Fung EC

Cureus, 2025

Abstract

Esophagitis dissecans superficialis (EDS) is an infrequently diagnosed benign esophageal disease that presents with sloughing of the esophageal mucosa into the esophageal lumen. It often presents after esophageal irritation but may also occur idiopathically. Treatment is approached by cessation of the offending agent and initiation of a proton pump inhibitor (PPI). We present the case of a 47-year-old female with persistent epigastric pain and dysphagia despite twice-daily PPI use. The patient had several known risk factors for EDS. Diagnosis was subsequently confirmed by upper endoscopy and histopathological analysis. The patient was advised to continue PPI treatment indefinitely.

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