Sleeve Gastrectomy in a Patient with Obesity and Ehlers-Danlos Syndrome: A Case Report

Amanda Belluzzi, M. Foletto

Global Surgery Case Reports, 2020

1 citation

Abstract

Ehlers-Danlos syndrome (EDS) is an inherited connective tissue disorder with a huge variety of signs and

symptoms. Gastrointestinal manifestations may be present in up to 50% of patients. We here report bariatric

surgery in a patient with EDS, focusing on management challenges, preoperative assessment and one-year

outcome. A 56-year-old woman with hypermobility-type (HM) EDS, BMI 42,5 kg/m2

and hypertension

underwent laparoscopic sleeve gastrectomy (LSG). She was uneventfully discharged on POD3. One-year

after the operation her BMI was 28,3 kg/m2

and hypertension receded. Postoperative upper GI series (POD60) did show neither reflux nor esophageal dysmotility. Bariatric surgery in patients with EDS can be

challenging due to the potential risks of wound healing. Proper preoperative assessment and follow up

should be strongly recommended.

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices Molecular & Cellular Proteomics, 2011
The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities Proceedings of the National Academy of Sciences, 2000
In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling British Journal of Pharmacology, 2007
In silico prediction of splice-altering single nucleotide variants in the human genome Nucleic Acids Research, 2014
In silico clinical trials: how computer simulation will transform the biomedical industry International Journal of Clinical Trials, 2016
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design Nature Communications, 2018

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free