Motor neurone disease and animal models
Abstract
Over the past several years, remarkable progress has been made in understanding the biological substrates of motor neurone disease (MND) (Kuncl et al 1992, Smith 1992, Williams & Windebank 1993). Genetic factors in the aetiology of MND have been identified, animal models have been developed and characterized, hypothetical pathogenetic mechanisms have been proposed and are being tested and promising therapeutic approaches are being explored.The investigation of MND is now one of the most exciting and challenging areas of research and provides a superb illustration of the dynamic interactions between clinical and basic research in neuroscience.
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