Fabrication and characterization of ZrO2 incorporated SiO2-CaO-P2O5 bioactive glass scaffolds
Abstract
Sol-gel chemistry offers a flexible, widely accepted methodology that enables the creation of a new generation of bioactive glass (BG). In the current study, a sol-gel method was used to synthesize ZrO2 incorporated 56SiO2-34CaO-10P2O5 mol% bioactive glass. The highly crystalline structure was composed of small zirconium oxide nanoparticles (ZrO2) of less than 200 nm in size. It was successfully fabricated using a hydrothermal method. Polyurethane foam (PU) was selected to fabricate a highly porous BG-ZrO2 scaffold using a foam replica technique. The physicochemical, morphological properties of the BG-ZrO2 compositions were evaluated using X-ray diffraction (XRD), Fourier transforms infrared (FTIR), thermo-gravimetric analysis (TGA), transmission electron microscope (TEM) and scanning electron microscope (SEM) with energy dispersive spectroscopy (EDS). In-vitro degradation analysis of the BG-ZrO2 scaffolds was performed after immersion of the samples in simulated body fluid (SBF). The incorporation of ZrO2 nanoparticles into the bioactive glass matrix enhances both the mechanical strength and thermal stability. Since the novel formed BG-ZrO2 scaffolds possesses respectable antibacterial properties against some bacterial strains, this renders it an ideal tissue engineering substitute, capable of reducing failure rates in implants.
Read the paper
Related studies
- The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
- The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
- In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
- In silico prediction of splice-altering single nucleotide variants in the human genome
- In silico clinical trials: how computer simulation will transform the biomedical industry
- In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.