Synthesis and characterization of chitosan-polyvinyl alcohol-bioactive glass hybrid membranes
Abstract
The tissue engineering strategy is a new approach for the regeneration of cementum, which is essential for the regeneration of the periodontal tissue. This strategy involves the cell cultures present in this tissue, called cementoblasts, and located on an appropriate substrate for posterior implantation in the regeneration site. Prior studies from our research group have shown that the proliferation and viability of cementoblasts increase in the presence of the ionic dissolution products of bioactive glass particles. Therefore, one possible approach to obtaining adequate substrates for cementoblast cultures is the development of composite membranes containing bioactive glass. In the present study, composite films of chitosan-polyvinyl alcohol-bioactive glass containing different glass contents were developed. Glutaraldehyde was also added to allow for the formation of cross-links and changes in the degradation rate. The glass phase was introduced in the material by a sol-gel route, leading to an organic-inorganic hybrid. The films were characterized by Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM) with electron dispersive spectroscopy (EDS) and X-ray diffraction (XRD) analysis. Bioactivity tests were also conducted by immersion of the films in simulated body fluid (SBF). Films containing up to 30% glass phase could be obtained. The formation of calcium phosphate was observed after the immersion of the films. A calcium phosphate layer…
How strong is the evidence?
Evidence Hub reads this as a experimental / empirical study, done in cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
- The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
- In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
- In silico prediction of splice-altering single nucleotide variants in the human genome
- In silico clinical trials: how computer simulation will transform the biomedical industry
- In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.