Risk factors for progression to type 2 diabetes in prediabetes: a systematic review and meta-analysis
Abstract
Prediabetes is the earliest identifiable stage of glycemic dysregulation, and its progression can be delayed by effective control of risk factors. Currently, various risk factors for the progression from prediabetes to type 2 diabetes mellitus (T2DM) need to be further summarized. This systematic evaluation of the risk factors for the progression of prediabetes to type 2 diabetes mellitus provides a theoretical basis for early recognition and intervention. The meta-analysis identifies the Fatty Liver Index as a significant risk factor [OR = 6.14, 95% CI (5.22, 7.22)] for the progression from prediabetes to type 2 diabetes, highlighting its predictive value. PubMed, Web of Science, Embase, The Cochrane Library, CNKI, WANFANG, and VIP databases were searched to collect cohort studies on risk factors for progressing to type 2 diabetes in prediabetes from inception to February 15, 2024. STATA 17.0 was used for Meta-analysis. A total of 59 studies were included, all of which were of medium to high quality. The factors were categorized into four major groups: sociodemographic factors, lifestyle factors, psychosocial factors, and comorbidities and clinical indicators. Meta-analysis results showed that sociodemographic factors [age [OR = 1.03, 95% CI (1.01, 1.04)], family history [OR = 1.48, 95% CI (1.36, 1.61)], male sex [OR = 1.13, 95% CI (1.08, 1.19)], high BMI [OR = 1.21, 95% CI (1.15, 1.27)], high waist circumference [OR = 1.49, 95% CI (1.23, 1.79)], and high waist-to-hip ratio…
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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