Bacterial Isolation and Antibiotic Resistance Patterns in Urinary Tract Infections: A Focus on Fosfomycin Resistance in E. coli
Abstract
Background: Urinary tract infections (UTIs) are one of the most common bacterial infections globally, with increasing antimicrobial resistance (AMR) posing a significant challenge to effective treatment.Objective: This study aims to isolate and identify bacterial uropathies, assess their antimicrobial susceptibility patterns, and determine the presence of Fosfomycin-resistant E. coli strains in a tertiary care hospital in Rajshahi, Bangladesh.Methods: A descriptive cross-sectional study was conducted at Rajshahi Medical College Hospital, Bangladesh, from January to December 2019.A total of 285 urine samples were collected from clinically suspected UTI patients.Bacterial identification was performed using culture, Gram staining, and biochemical tests.Antimicrobial susceptibility testing was conducted using the Kirby-Bauer disk diffusion method, following Clinical and Laboratory Standards Institute (CLSI) guidelines.Fosfomycin-resistant E. coli isolates were subjected to polymerase chain reaction (PCR) for the detection of the fosA3 gene.Data analysis was performed using SPSS version 24.0.Result: Among 285 participants, 53.68% (153/285) were culture positive, with E. coli (60.49%) being the most prevalent isolate.Gram-negative bacteria accounted for 83.95% of isolates.E. coli exhibited high resistance to Amoxiclav (79.59%) and Ciprofloxacin (56.12%), while showing highest sensitivity to Imipenem (88.78%).Fosfomycin resistance was detected in only 2 E. coli isolates.Other…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 285 participants or records.
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