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Evaluation of long‐acting cabotegravir safety and pharmacokinetics in pregnant women in eastern and southern Africa: a secondary analysis of HPTN 084

S. Delany-Moretlwe, Brett Hanscom, Xu Guo, Clemensia Nkabiito, P. Mandima, P. Nahirya, J. Mpendo, Muchaneta Bhondai-Mhuri et al.

Journal of the International AIDS Society, 2025

19 citations

Abstract

Long‐acting injectable cabotegravir (CAB‐LA) for pre‐exposure prophylaxis significantly reduced HIV acquisition in HPTN 084. We report on the safety and CAB‐LA pharmacokinetics in pregnant women during the blinded period of HPTN 084.

How strong is the evidence?

Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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