Efficacy and safety of low-intensity shockwave therapy on lower urinary tract symptoms in non-prostatic condition: A systematic review and meta-analysis
Abstract
ABSTRACT Objective To evaluate the efficacy and safety of low-intensity shockwave therapy (LiSWT) for non-prostatic storage lower urinary tract symptoms (LUTS), including overactive bladder (OAB), stress urinary incontinence (SUI), and interstitial cystitis/bladder pain syndrome (IC/BPS). Methods A systematic search of MEDLINE, Embase, CENTRAL, and ClinicalTrials.gov was conducted up to September 2024. Randomized controlled trials (RCTs), prospective studies, and single-arm studies evaluating LiSWT for non-prostatic LUTS in adults were included. Outcomes assessed included urinary frequency, urgency, nocturia, pain for IC/BPS, pad-test for SUI, uroflowmetry parameters, and questionnaire-based symptom scores. Risk of bias was assessed using Cochrane Risk of Bias 2.0 and ROBINS-I. Random-effects meta-analysis was performed. Results Twelve studies (six RCTs, six observational) involving 624 participants were included. LiSWT significantly reduced urinary frequency in OAB and IC/BPS patients, with SUI improvements emerging at 12 weeks. Compared to sham treatment, only the OAB group showed significant reductions at 4 weeks. Urgency symptoms improved in OAB and SUI, but differences from sham were not significant. Nocturia improved in OAB and IC/BPS but was not significantly different from sham. Overall pain reduction was significant for IC/BPS (MD −1.61 (95%CI −2.21 to −1.02)). In SUI, most participants had >50% improvement in pad-test weight, but the mean difference compared to…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 624 participants or records.
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