Food Protein-Induced Enterocolitis Syndrome in Children: A Case Report
Abstract
Food protein-induced enterocolitis syndrome (FPIES) is a rare form of non-IgE-mediated food allergy that remains underrecognized and is often responsible for diagnostic delay. We report the case of an eight-year-old child with a history of celiac disease, presenting with recurrent episodes of abdominal pain and vomiting occurring in a delayed manner after ingestion of specific foods. The clinical presentation was characterized by delayed, intermittent, and reproducible gastrointestinal symptoms. Standard allergy investigations, including specific IgE testing and prick-to-prick testing with the suspected food allergens, were negative, supporting a non-IgE-mediated mechanism strongly suggestive of FPIES. Clinical evolution was marked by improvement following elimination of the implicated foods. This case highlights the diagnostic challenges of this condition and emphasizes the importance of a rigorous clinical approach in children presenting with unexplained gastrointestinal symptoms.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
- Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
- Gastrointestinal manifestations in COVID-19
- COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
- Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.