Ondansetron for the Management of Vomiting in Children with Gastroenteritis: A Critical Review of the Literature
Abstract
The purpose of this study was to review the current knowledge on the efficiency, effectiveness, and safety of ondansetron in the treatment of vomiting due to acute gastroenteritis in children. A Medline search using the terms ondansetron, vomiting, and/or gastroenteritis, limited to the pediatric population, yielded only 4 randomized, double-blind controlled clinical trials. Analysis of their primary and secondary outcomes, with calculation of the number needed to treat (NNT), showed that ondansteron is a promising pharmacologic solution for rehydration in this setting, but it harbors a risk of diarrheal complications. Further well-designed prospective studies are warranted to reach a definitive conclusion.
Read the paper
Related studies
- Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
- Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
- Gastrointestinal manifestations in COVID-19
- COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
- Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.