ROLE OF ORAL ONDANSETRON AS AN ADJUCNT TO ORAL REHYDRATION THERAPY IN ACUTE GASTROENTERITIS: Oral Ondansetron
Abstract
Objective: To evaluate the role of oral ondansetron as an effective measure to facilitate oral rehydration in acute gastroenteritis.Study Design: Randomized controlled trail.Place and Duration of Study: Army medical college, Military hospital Rawalpindi, from Mar 2017 to Sep 2017.Material and Methods: One hundred and forty children with clinical diagnosis of acute gastroenteritis with mild to moderate dehydration were randomized into two equal groups. Group 1 was treated according to the WHO criteria with only ORS in a dose of 75ml/kg body weight. Group 2 received ondansetron before ORS as a single oral dose of 0.2mg/kg body weight.Results: The difference between improvement in drinking ability and hydration status between the two groups was highly significant (p<0.001).Conclusion: Ondansetron markedly improved the hydration status and drinking ability of the children by reducing nausea and vomiting.
How strong is the evidence?
Evidence Hub reads this as a randomized trial. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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