Relationship between Enteric Pathogen and Acute Gastroenteritis Disease Severity: A Prospective Cohort Study
Abstract
Background: Acute gastroenteritis is one of the top reasons children are brought for emergency department care. Little is known about the association between specific pathogens and disease severity in children with vomiting/diarrhea in the outpatient setting. Recent advances in diagnostic approaches enabling the simultaneous detection of common pathogenic enteric bacteria, viruses, and parasites have become readily available. Clinicians can request testing be performed to rapidly and comprehensively identify etiologic pathogens. While such knowledge can be used to optimize therapy, it also has the potential to predict disease severity. Such knowledge can aid clinical …
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
- Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
- Gastrointestinal manifestations in COVID-19
- COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
- Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.