Higher admission serum total carbon dioxide is independently associated with early seizure recurrence in children with benign convulsions with mild gastroenteritis
Abstract
Background Readily accessible biomarkers for early seizure recurrence in benign convulsions with mild gastroenteritis (CwG) are lacking. We evaluated whether admission serum total carbon dioxide (TCO2), a routine venous surrogate for bicarbonate, predicts seizure recurrence within 48 h in children with CwG. Methods This retrospective study included children aged 6 months to 6 years diagnosed with CwG (2020–2026). Multivariable logistic regression evaluated the association between admission venous TCO2 and seizure recurrence within 48 h, adjusting for age and anticonvulsant use. Model performance underwent bootstrap internal validation. TCO2/bicarbonate concordance was assessed in a paired subset. Results Of 86 children (median age 14.5 months), 23 (26.7%) experienced recurrence. Median TCO2 was higher in the recurrence group (17.4 vs. 15.1 mmol/L, P = 0.007). In multivariable analysis, higher TCO2 (odds ratio 1.235, 95% confidence interval 1.053–1.448; P = 0.009) and younger age (P = 0.016) were independently associated with recurrence. The optimism-corrected area under the curve was 0.710, calibration slope was 0.748, and Brier score was 0.164. A TCO2 cutoff of 16.25 mmol/L yielded 78.3% sensitivity, 61.9% specificity, and 88.7% negative predictive value. In 29 paired samples, venous TCO2 and arterial bicarbonate were strongly correlated (r = 0.966, P < 0.001). Conclusions Higher admission serum TCO2 was independently associated with early seizure recurrence in CwG. As a…
Read the paper
Related studies
- Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
- Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial
- Gastrointestinal manifestations in COVID-19
- COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
- Persistent gut barrier damage and commensal bacterial influx following eradication of Giardia infection in mice
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.