Comparative analysis of serious adverse effects of antidiabetic drugs and complications associated with type II diabetes mellitus
Abstract
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major global health problem for which a wide range of antidiabetic medications are available. Adverse effects of antidiabetic medications may negatively affect patients' health and treatment adherence. In Egypt, limited data are available regarding the adverse-effect profiles of antidiabetic agents.
AIM: This study aimed to compare safety profiles, treatment-related adverse effects, and diabetes-related complications associated with commonly prescribed antidiabetic medications.
MATERIALS AND METHODS: A multicenter, cross-sectional observational study was conducted across diabetes outpatient clinics in Egypt from February 2024 to May 2024. Adult patients with type 2 diabetes on antidiabetic regimens were enrolled. Data was collected through medical records and patient interviews, including demographics, clinical history, laboratory results, diabetes complications, and treatment-related adverse events. Univariate logistic regression analyses were performed to assess the associations between antidiabetic medications and diabetes-related complications and adverse outcomes. Unadjusted odds ratios (ORs) with 95% confidence intervals were reported. Statistical significance was set at p-value ≤ 0.05.
RESULTS: Several statistically significant associations were observed between the use of different antidiabetic medications and the prevalance of side effects and diabetes-related complications. Among 1,534 participants, insulin was…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 1,534 participants or records.
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