Taste Masking Strategies for Ondansetron Orodispersible Tablets in Pediatric Drug Delivery
Abstract
Ondansetron is a common antiemetic prescribed in the treatment of nausea and vomiting that comes with chemotherapy, radiotherapy, and even after surgery. However, due to the taste that is bitter in nature, it poses a major challenge in administration to children, and this leads to low compliance rates. ODTs are now an available dose form in children as they dissolve fast in the mouth without water. However, taste masking is an important need that must be effectively addressed so as to make it acceptable and therapeutically conformant. The reviewed content is concentrated on modern taste-masking approaches which are utilized in the production of ondansetron orodispersible pediatric tablets to deliver drugs orally. Different methods of formulation such as ion-exchange resins, microencapsulation, polymer coating, inclusion complexation and solid dispersion are mentioned in connection with their mechanism, merits, and limitations. Special stress is laid on higher microencapsulation technologies and ion-exchange resin complex which are effective in avoiding the release of the drug to the oral cavity and allowing fast release in the gastrointestinal tract. Besides this, the review also cites the influence of superdisintegrants, excipient choice, and formulation optimization in the rapid disintegration of tablets and the acceptable taste masking. Moreover, recent progress in the design of formulations in pediatrics, regulatory factors, and quality assessment parameters of…
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