Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2019
Abstract
Background: Allergic rhinoconjunctivitis is commonly caused by allergens from the birch homologous group, which includes birch, oak, hazel, alder and hornbeam, all characterised by having Bet v 1 homologous allergens that extensively cross-react.The current study characterized the ability of the SQ tree SLIT-tablet (containing birch extract) to induce immunological responses that cross-react with all species in the birch homologous group.Methods: Blood samples were collected from adults who had moderate to severe rhinoconjunctivitis induced by birch pollen who were treated with the SQ tree SLIT-tablet for 24 weeks (ClinicalTrials.govIdentifier NCT02481856).Serum IgE (pre-treatment) and IgG4 (posttreatment) specific for birch, oak, hazel, alder, beech, chestnut and hornbeam were measured by standard ImmunoCAP.Correlation analyses and inhibition assays were performed to evaluate immunological cross-reactivity.The study was approved by the Ontario IRB, approval number 12069.Results: The analyses demonstrated a high level of correlation between IgE reactivity (pre-treatment) between birch and alder, hazel, hornbeam and oak.The strongest correlation in IgE titers was observed between birch and alder (r = 0.98), and the weakest between birch and oak (r = 0.83).A strong correlation between IgE titers was also observed for beech, but not for chestnut.The analyses also demonstrated a high level of correlation between IgG4 reactivity (treatment-induced) towards birch and alder, hazel,…
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