Relationship between advanced glycation end-products, serum carnosinase-1 and diabetic nephropathy and diabetic retinopathy
Abstract
Background: This article analysed the relationship between serum advanced glycation end-products (AGEs), carnosinase-1 (CN-1) and diabetic nephropathy (DN) and diabetic retinopathy (DR).
Methods: 150 patients with type 2 diabetes mellitus (DM2) were grouped: DN and non-DN, DR and non-DR groups. Fasting venous blood was collected, and serum levels of AGEs and CN-1 were detected. Pearson's correlation (PC) test was adopted to analyse their correlation with DN and DR, and multivariate logistic regression (MLR) analysis was adopted.
Results: There were 48 DN cases, 102 non-DN cases, 20 DR cases, and 130 non-DR cases in 150 patients with DM2. As against the non-DN group, the serum levels of AGEs and CN-1 in the subjects with DN were markedly increased. Similarly, the serum levels of AGEs and CN-1 in subjects with DR were also significantly increased compared to the non-DR group. The results of correlation analysis revealed that the levels of serum AGEs and CN-1 were positively correlated with the occurrence of DN and DR. Serum AGEs and CN-1 levels were identified as independent risk factors (IRF) for DN and DR (all P< 0.05).
Conclusions: AGEs and CN-1 may become new targets for the diagnosis and treatment of diabetic microvascular complications.
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