Correlation risk analysis of serum inflammatory factors and 25-hydroxyvitamin D in vascular lesions in type 2 diabetes patients
Abstract
Background: To explore serum inflammatory factors and 25-hydroxyvitamin D and diabetic vascular lesions in patients with T2DM.
Methods: A total of 362 adult (aged 18 years) patients with T2DM hospitalised from April 2022 to June 2024 were selected as research subjects. A patient's body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), age, sex, and length of illness were among the general data gathered. Blood parameters, glycated haemoglobin (HbA1c), fasting blood glucose (FPG), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6)], and 25-hydroxyvitamin D [25(OH) D] were determined. The homeostatic model assessment of insulin resistance index (HOMA-IR) and the systemic inflammatory index (SII) were computed. The vascular lesions were divided into three groups: the simple T2DM group (155 patients), the T2DM microvascular lesion group (122 patients), and the T2DM macrovascular lesion group (85 patients). One-way analysis of variance, the Kruskal-Wallis H test, or the c2 test was used for comparisons among multiple groups. The relationship between 25(OH) D and several inflammatory markers was examined using Spearman correlation analysis, and the factors influencing diabetic vascular lesions were analysed using multivariate logistic regression analysis.
Results: The levels of 25(OH) D in both the T2DM microvascular lesion group and the T2DM…
Read the paper
Related studies
- Contribution of social science to large scale biodiversity conservation: A review of research about the Natura 2000 network
- The alignment of agricultural and nature conservation policies in the European Union
- Determination of ecological significance based on geostatistical assessment: a case study from the Slovak Natura 2000 protected area
- Routledge Handbook of the Study of the Commons
- Farmers' acceptance of results-based agri-environmental schemes: A German perspective
- Approaches to Identify the Value of Seminatural Habitats for Conservation Biological Control
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.