The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma
Abstract
Aim: The aim of this study was to evaluate the value of stimulated tireoglobulin (sTg) in patients with differentiated thyroid carcinoma (DTC) after the surgery and during the follow up period comparing the findings with the diagnostic 131I-whole body scan (DxWBS), posttherapy 131I- scan (TxWBS) and clinical findings. Patients and methods: A retrospective review comprised 164 DxWBS of 93 patiens of whom 40 patients had only postsurgical scan while in others control DxWBSs were included as well. Scan results were considered positive if any focal uptake in the neck or elsewhere was visible and negative if the physiological radioiodine accumulation persisted. Stimulated Tg is considered positive if higher than 2ng/ml. Results: Negative value of sTg was detected in 56 cases with negative DxWBS scan results and positive sTg was concordant with higher values of sTg in 78 cases. Overall concordant findings were detected in 82% of cases. Discordant findings were detected in 30 cases (18%) of which in 20 (12%) DxWBS scan was positive, while in 10 (6%) cases DxWBS scan was negative and sTg positive. All the patients with discordant findings received radioidine ablation/therapy. Posttherapy whole body scan was concordant with the results of DxWBS in 20 patients with positive DxWBS and negative sTG and in 3 patients with negative DxWBS and positive sTG. However, negative TxWBS scan result was found in 7 of 10 patients with negative DxWBS and positive sTg. Conclusion: Our results showed…
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