Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate
Abstract
Astaxanthin is a carotenoid compound that has several beneficial qualities, including antioxidant, anti-inflammatory, antiapoptotic, and antidiabetic effects. This study examined the effects of astaxanthin supplementation on inflammation-related microRNAs, lysophosphatidylcholine, and α-hydroxybutyrate in individuals with Type 2 diabetes. Fifty people with Type 2 diabetes volunteered in a placebo-controlled, randomized, double-blind clinical trial. Subjects were randomly determined to consume either 10 mg of astaxanthin (n = 25) or a placebo (n = 25) for 12 weeks. Quantitative real-time PCR was employed to assess the expression of inflammation-related microRNAs in peripheral blood mononuclear cells both before and after the intervention, and we employed ELISA to ascertain the serum levels of lysophosphatidylcholine and α-hydroxybutyrate. After 12 weeks of supplementation, in comparison with placebo, astaxanthin supplementation resulted in a noteworthy decrease (p p Trial Registration: Iranian Registry of Clinical Trials (IRCT): IRCT20190305042939N1.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 25 participants or records.
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