Potassium channels in vascular smooth muscle cells
Abstract
Vascular smooth muscle cells express several types of potassium (K+) channels that control physiological functions including contractility, migration, proliferation, and differentiation. Five primary classes of K+ channel are present in vascular smooth muscle cells: large-conductance Ca2+-activated K+ (BK), voltage-dependent K+ (KV), inward-rectifier K+ (Kir), adenosine triphosphate (ATP)-sensitive K+ (KATP), and two-pore domain (tandem pore domain) K+ (K2P) channels. Vascular smooth muscle cells can express specific submembers, splice variants, and auxiliary subunits of these five K+ channel classes to customize their properties. Expression patterns of K+ channels in smooth muscle cells can vary depending on vessel type, size, and anatomical origin. The expression, activity, trafficking, and surface abundance of K+ channels can be regulated by a wide variety of stimuli, including membrane voltage, ions, molecules, lipids, and proteins, including those generated by signal transduction pathways. K+ channel function can exhibit sexual dimorphism, change in conditions such as pregnancy and aging, and alter in different diseases, including systemic and pulmonary hypertension, diabetes mellitus/metabolic syndrome, and brain disorders. Genetic mutations in genes that encode K+ channels are also associated with pathological alterations in vascular smooth muscle function. Here, we provide a comprehensive summary of approximately 40 years of literature investigating the expression,…
Read the paper
Related studies
- Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
- Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases
- Antioxidants, inflammation and cardiovascular disease
- Application of Metabolomics in Alzheimer’s Disease
- Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
- Nutritional essentiality of sulfur in health and disease
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.