Evaluation of Homocysteine, D-dimer and Biochemical Parameters in Relation to Chronic Kidney Disease Stages among Patients Attending Specialist Hospitals in Enugu, Enugu State
Abstract
Abstract Background of the study: Chronic kidney disease is a major health challenge ravaging the world due to its progressive irreversible effect. The related morbidity and mortality poses a great concern to developing countries like Nigeria owing to the clinically silent onset of the disease and the underlying co-morbidities. People with chronic kidney disease are predisposed to various biochemical and fibrinolytic alterations arising due to immune activation and endothelial dysfunction thereby exposing them to thrombotic events. Aim: The aim of the study was to evaluate the homocysteine, D-dimer and biochemical parameters in relation to chronic kidney disease stages among patients attending specialist hospitals in Enugu, Enugu State. Methodology: The study adopted a cross sectional research design. A total of one hundred and eighty consented participants comprising of one hundred diagnosed chronic kidney disease patients and eighty apparently healthy age and sex matched controls within 18-65 years from Enugu State University Teaching Hospital, Parklane and University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu were recruited for this study. Ethical approval was obtained and demographic data were obtained using a well-structured questionnaire. Serum electrolyte was assayed using Exias biochemical autoanalyzer while urea and creatinine was determined using Cobas 111 autoanalyzer. Quantitative evaluation of homocysteine and D-dimer levels were done using enzyme linked…
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