Untargeted metabolomics for the early detection of preeclampsia: A systematic review of human studies
Abstract
This systematic review synthesizes current evidence on metabolomics-based biomarkers for the early prediction or diagnosis of preeclampsia and highlights promising candidates with potential clinical application. Following PRISMA guidelines, a comprehensive search was performed in PubMed, Cochrane Library, Web of Science, and ClinicalTrials.gov up to September 2024, using predefined terms related to preeclampsia, metabolomics, and pregnancy. Study selection and risk of bias assessment were conducted with CADIMA, applying PICO-based inclusion criteria and predefined quality appraisal standards. Of 112 records identified, 16 were duplicates, 57 were excluded after title and abstract screening, and 31 after full-text review, leaving 12 studies for inclusion. These comprised cohort, case-cohort, case-control, validation, prospective control, and translational designs. Data extraction captured study characteristics, populations, methodologies, biological matrices, and main findings. Considerable heterogeneity was observed across studies, with limited overlap in identified metabolites. Nonetheless, alanine was reported in serum, lactate was observed in both serum and urine, and glutamate and glutamine were detected across serum, plasma, and placental tissue. These metabolites, interconnected through the Cori and glucose-alanine cycles, have been linked to hepatic dysfunction, immune regulation, and excitotoxicity. Overall, metabolomics shows strong potential as a sensitive tool for…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
- Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases
- Antioxidants, inflammation and cardiovascular disease
- Application of Metabolomics in Alzheimer’s Disease
- Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review
- Nutritional essentiality of sulfur in health and disease
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.