Effect of rumen-protected methionine on placenta metabolism, animal performance, and immune-metabolism of dairy cows during the periparturient and early lactation periods
Abstract
During the periparturient period, dairy cows experience major physiological, nutritional, metabolic, and immunological events. Methionine, besides been the first limiting amino, is an important precursor of antioxidants and methyl donor. Therefore, our objective was to examine the effects of enhancing methionine supply on performance, immunometabolic responses, and utero-placental metabolism of dairy cows. Sixty multiparous Holstein cows were used in a block design and assigned to a control diet or the control plus rumen-protected methionine (MET; Mepron, Evonik Nutrition & Care GmbH, Germany). Mepron was fed from −28 to 60 d relative to parturition at a rate of 0.09% and 0.10% of DM during the prepartum and postpartum period, respectively. That rate ensured that the ratio of lysine to methionine in the metabolizable protein was close to 2.8:1. Compared with control, during the fresh period (1-30 days in milk) MET increased intake by 1.7 kg/d, milk yield by 4.1 kg/d, fat yield by 0.17 kg/d, and milk protein yield by 0.20 kg/d. During the high-producing period (31-60 days in milk), cows fed MET increased intake by 1.45 kg/d, milk yield by 4.4 kg/d, fat yield by 0.19 kg/d, and milk protein yield by 0.17 kg/d, compared with control. MET supplementation reduced plasma fatty acids in the fresh period and decreased γ-glutamyl transferase, cholesterol and paraoxonase indicating better liver function. Among the inflammation biomarkers measured, MET led to greater albumin (negative…
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