System-level metabolic effects of trematode infections in rodent models
Abstract
Background: Trematode infections impose a great burden on the developing world by impairing life quality, productivity and life span of an individual. The prerequisite for efficient treatment and control of the diseases is the use of a quick and sensitive diagnostic tool which could replace the multi-diagnostic approach that is still used. The metabolic profiling approach implies the use of spectroscopic tools such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) on potentially interesting biofluids and tissues, and is coupled with multivariate mathematical data modelling. It has been applied to many different field of research, such as biochemistry, medical sciences, drug pathway discovery, non-communicable diseases, nutrition and psychological disorders, and has been established as an efficient method for biomarker recovery and pathway deciphering. There is growing interest in metabolic profiling in systems biology. The first attempt to bring together metabolic profiling with the epidemiology of neglected tropical diseases was in mid-2002, when urine samples were obtained from more than 500 individuals in a rural Western part of Côte d’Ivoire. However, it was impossible to extract any meaningful information with regard to specific parasitic infection. The high degree of metabolic variation of the studied population in terms of age, genetic and nutritional background and the fact that the majority of individuals harboured three or more parasites…
How strong is the evidence?
Evidence Hub reads this as a thesis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 500 participants or records.
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