Overview on spectrophotometric and chromatographic methods for estimation of atorvastatin calcium and sildenafil in bulk and in different dosage forms
Abstract
Erectile dysfunction (ED) is a major health problem affecting 52% of men between 40 and 70 years.The association between ED and hypercholesterolaemia has also been studied extensively.Combination drug products occupy a time-honored and important role in therapeutics.The combination of Atorvastatin Calcium and Sildenafil is commercially available in tablet form to control erectile dysfunction.The Atorvastatin calcium and Sildenafil co-formulation, the IIEF-5 score was significantly decreased, maintaining cholesterol level.Analysis of samples with numerous components presents a major challenge in modern analysis.This article narrates different chromatographic (HPLC, HPTLC, UPLC, LC) & different spectrophotometric method (UV) for determination of the Atorvastatin Calcium and Sildenafil single drug as well as combination with other drug.
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