Balance Interventions to Improve Upright Balance Control and Balance Confidence in People with Motor-Incomplete Spinal Cord Injuries or Diseases: A Systematic Review and Meta-Analysis
Abstract
OBJECTIVES
To assist with clinical decision-making, evidence syntheses are needed to demonstrate the efficacy of available interventions, and examine the intervention components and dosage parameters. This systematic review and meta-analysis describes the efficacy, components and dosage of interventions targeting upright balance control, balance confidence and/or falls in adults with motor incomplete spinal cord injuries/diseases (SCI/D).
DATA SOURCES
A search strategy following the PICO framework was developed. Six databases were searched: APA PsychInfo, CINAHL, Embase, Emcare Nursing, Web of Science CC, and Medline.
STUDY SELECTION
Title, abstract and full-text screening were conducted by two researchers independently. Inclusion criteria included: 1) adults with chronic, motor-incomplete SCI/D; 2) physical intervention targeting upright postural control; and 3) clinical and/or biomechanical measures of upright balance control and/or balance confidence and/or documentation of falls.
DATA EXTRACTION
Participant characteristics, balance intervention details, adverse events and study results were extracted. The Downs and Black Checklist assessed methodological quality. Meta-analyses on pre-post intervention outcomes and a meta-regression of dosage were completed. The GRADE approach was used to evaluate the quality of the evidence.
DATA SYNTHESIS
The search returned 1,664 unique studies; 26 were included. Methodological quality was moderate to good. Participants were 500…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 500 participants or records.
Read the paper
Related studies
- Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
- Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens
- Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury
- The intratumoral administration of ferucarbotran conjugated with doxorubicin improved therapeutic effect by magnetic hyperthermia combined with pharmacotherapy in a hepatocellular carcinoma model
- Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer
- In vivo tracking of bioorthogonally labeled T-cells for predicting therapeutic efficacy of adoptive T-cell therapy
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.