Indocyanine green (ICG) fluorescence angiography-guided arthroscopic rotator cuff surgery: A randomized controlled trial
Abstract
BACKGROUND
Indocyanine green (ICG) fluorescence angiography is used to evaluate tissue vascularity across various surgical fields. However, ICG has not been widely utilized in rotator cuff tendon surgery, which involves poorly vascularized tissue. In this study, we investigated the efficacy of ICG-guided arthroscopic rotator cuff repair (RCR) to evaluate the vasculature of the débridement margin and the tendon-bone interface and compared it with the conventional arthroscopic technique.
METHODS
Patients with small- to medium-sized rotator cuff tears were recruited from February 2020 to February 2022 and were randomly assigned to either the ICG-guided RCR group or the conventional RCR group, with 32 patients in each group. Standard arthroscopic RCR was performed in both groups; however, in the ICG group, ICG was administered intravenously during surgery to assess blood perfusion in the tissue. Tear margin débridement was conducted while monitoring the enhancement of ICG, and suturing was performed after confirming the blood supply at the tendon-bone interface. The primary outcome was the re-tear rate, determined using the Sugaya classification based on MRI conducted six months post-surgery. Secondary outcomes included the range of motion and patient-reported outcome measures (PROMs), such as American Shoulder and Elbow Surgeons (ASES) score, Constant-Murley Score (CMS), Single Assessment Numeric Evaluation (SANE), and pain VAS, as well as the prevalence of complications. The…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 58 participants or records.
Read the paper
Related studies
- Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
- Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens
- Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury
- The intratumoral administration of ferucarbotran conjugated with doxorubicin improved therapeutic effect by magnetic hyperthermia combined with pharmacotherapy in a hepatocellular carcinoma model
- Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer
- In vivo tracking of bioorthogonally labeled T-cells for predicting therapeutic efficacy of adoptive T-cell therapy
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.