Evidence Hub

A Case Report on Delayed Hypoxic Encephalopathy after Carbon Monoxide Intoxication Treated with Korean Medicine

Su-hyeon Lee, Jun-young Hur, In-chan Seol, Yoon-sik Kim, Ho-ryong Yoo

The Journal of Internal Korean Medicine, 2025

Abstract

Objective: CO poisoning, caused by a colorless, odorless, and tasteless toxic gas, binds hemoglobin with over 200 times the affinity of oxygen, causing tissue hypoxia and central nervous and cardiovascular damage. Although hyperbaric oxygen therapy and supportive care are commonly used during the acute phase, neurological sequelae-including delayed hypoxic encephalopathy (DHE)-may develop after initial recovery. This case report presents the clinical course and potential benefits of integrative Korean medicine for improving neurological function and daily living in a patient with DHE following CO poisoning.Case Presentation: A 51-year-old male with DHE presented with bilateral upper- and lower-limb weakness, dysphagia, dysarthria, cognitive impairment, and gait disturbance. Diagnosed with Qi and blood deficiency, he received a 43-day integrative Korean medicine regimen including modified Doksampalmul-tang, Daseunggi-tang, Oryeong-san, acupuncture, moxibustion, and electrical stimulation. Neurological functions gradually improved, with significant gains in K-MBI, MRS, GCS, and NIHSS scores, restoring independence in daily activities.Conclusion: Integrative Korean medicine treatment may support functional recovery in patients with DHE following CO poisoning. Multicenter prospective studies are warranted to confirm efficacy and elucidate mechanisms.

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free