GS-441524 Treatment in a Cat With Feline Infectious Peritonitis Virus and Pyogranulomatous Transverse Colon Lesion
Abstract
Background/Aim: Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV), manifesting as effusive (wet) or non-effusive (dry) forms. Granulomatous lesions in the gastrointestinal tract, particularly the colon, are rare and pose diagnostic and therapeutic challenges. Case Report: A 7-year-old castrated male domestic shorthair cat (4.1 kg) presented with anorexia and vomiting. Blood tests showed an albumin:globulin ratio of 0.5, a mild elevation in aspartate aminotransferase, mild leukocytosis, and a severe elevation of feline serum amyloid A. The abdominal ultrasound and computed tomography imaging showed a mass in the transverse colon and surrounding mesenteric lymph nodes. The mass was observed to be relatively well vascularized, with areas of low-density uneven necrosis. Histological examination revealed severe pyogranulomatous inflammation with macrophages, neutrophils, and lymphocytes predominantly present in both the affected colon and lymphoid tissues. Immunohistochemistry for feline infectious peritonitis (FIP) virus antigen of the lesion showed a strong positive result, confirming limited and localized lesion induction by FIP virus infection. The cat received GS-441524 for 12 weeks, resulting in clinical improvement, lesion resolution, and normalized lab results. RT-PCR and antibody tests were negative post-treatment. Conclusion: This case report describes a rare presentation of FIP virus infection, characterized by localized lesions…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
- Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens
- Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury
- The intratumoral administration of ferucarbotran conjugated with doxorubicin improved therapeutic effect by magnetic hyperthermia combined with pharmacotherapy in a hepatocellular carcinoma model
- Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer
- In vivo tracking of bioorthogonally labeled T-cells for predicting therapeutic efficacy of adoptive T-cell therapy
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.