Effectiveness of contemporary treatments for iatrogenic urethral strictures following endoscopic management of benign prostatic hyperplasia: a comprehensive review
Abstract
Iatrogenic urethral strictures represent a relevant complication following endoscopic surgical treatment for benign prostatic hyperplasia, potentially leading to significant morbidity and impaired quality of life. Despite advances in endoscopic technologies, urethral trauma related to prolonged operative time and large-caliber instruments remains a concern. The optimal management of urethral strictures secondary to surgery is still debated, and high-quality evidence comparing endoscopic and open reconstructive approaches is lacking. This systematic review aimed to evaluate the efficacy and safety of contemporary treatments for iatrogenic urethral strictures following endoscopic management of benign prostatic hyperplasia. A systematic review was conducted according to PRISMA guidelines and registered in PROSPERO (CRD42024604611). MEDLINE, Embase, and the Cochrane Library were searched from 2000 to June 2025. Studies reporting outcomes of endoscopic or open surgical treatments for urethral strictures following benign prostatic hyperplasia surgery were included. Data extraction focused on patient characteristics, stricture features, treatment modality, success rates, complications, and follow-up. Due to substantial heterogeneity, a meta-analysis was not performed. Eleven studies comprising a total of 610 patients were included. Of these, 443 (73%) patients underwent primary treatment for urethral stricture, while 167 (27%) were treated for recurrent disease. The bulbar and…
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.