Efficacy of Prunus africana, Urtica dioica and Epilobium angustifolium in patients with benign prostatic hyperplasia
Abstract
. Benign prostatic hyperplasia (BPH) is a prevalent condition affecting aging males, causing lower urinary tract symptoms (LUTS) that affect the quality of life of patients. The present study aimed to assess the efficacy and safety of a combination of Prunus africana, Urtica dioica and Epilobium angustifolium extracts (Progamet), in conjunction with stan‑ dard alpha blocker therapy, for the management of symptoms of BPH. The present study was an observational, controlled mono‑centric trial including 92 male patients clinically diagnosed with BPH. The treatment group (n=46) received Progamet and alpha blockers for 90 days, while the control group (n=46) received alpha blockers alone. The primary endpoint was a change in the International Prostate Symptom Score (IPSS) after a period of 3 months. Secondary endpoints included urinary flow (Q‑max), erectile function assessed using the International Index of Erectile Function (IIEF) score and safety. The treatment group exhibited a significant reduc‑ tion in IPSS compared with the control group. The results of the present study also demonstrated that the Q‑max was significantly increased in the treatment group, and there was a significant improvement in erectile function based on the IIEF score. Progamet was well‑tolerated, with mild gastrointestinal side‑effects reported in a small number of patients. On the whole, the results of the present study highlight the potential of Progamet as an alternative or complementary treatment…
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.