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Real‐World Long‐Term Outcomes of Rezūm Therapy for Large‐Volume Benign Prostatic Hyperplasia: A Multicenter Cohort Study

Liberty Liu, M. H. B. Siqueira, N. Bhojani, Bilal Chughtai, Kevin C. Zorn, L. Cindolo, Giovanni Ferrari, K. Lajkosz et al.

Lower urinary tract symptoms, 2026

1 citation

Abstract

Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in aging men. Patients with large prostates (≥ 80 mL) often experience more severe symptoms and have limited minimally invasive treatment options. Water vapor thermal therapy (Rezūm) has demonstrated efficacy in moderate‐sized glands, and emerging evidence including multicenter cohorts and systematic reviews suggests efficacy in larger glands. However, long‐term real‐world multicenter data remain limited. This study evaluates the effectiveness of Rezūm therapy in men urinary status outcomes, sexual function, and prostate size in a large, multicenter real‐world cohort with extended follow‐up.

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